By Denham M.C., Whittaker J.
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Furthermore, alveolar macrophages but not blood monocytes Immune responses to HIV expressed increased levels of LPS-stimulated mRNA for TNFa, IL-1~, IL-6, during both early and late stages of HIV -1 infection regardless of virus load. This suggests that alveolar macrophages may serve as a reservoir for virus in the late stages of disease and yet contribute to immunopathogenesis of lung disease in both early and late stages through increased cytokine production. Macrophage-HIV relationship There are important differences in the outcome of HIV infection of monocytesl tnacrophages as compared to CD4 lymphocytes.