A Bayesian approach to disease gene location using allelic by Denham M.C., Whittaker J.

By Denham M.C., Whittaker J.

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AIDS, 4, 361-68. M. and Shellito, J. (1989) Effects of human immunodeficiency virus on pulmonary host defenses. Sem. Respir. , 4,75-84. , Spock, A. et al. (1981) Plasma proteins of the bronchoalveolar surface of lungs of smokers and non-smokers. Am. Rev. Respir. , 124, 72-79. G. J. (1983) Immunopharmacology of lung surfactant, in Immunopharmacology of the Lung: Lung Biology in Health and Disease series (ed. H. Newball) Executive ed. C. LenFant. Marcel Dekker, New York. , Amiot, M. et al. (1984) A novel human leucocyte differentiation antigen: monoclonal antibody anti-D44 defines a 28Kd molecule present on immature haematological cells and a subpopulation of mature T cells.

AIDS Res. Hum. , 6, 431-4l. , Gehr, P. et al. (1982) Cell number and cell characteristics of the normal human lung. Am. Rev. Respir. , 126, 332-37. E. J. (1985) Evaluation of natural killer activity in patients with persistent and generalized lymphadenopathy and acquired immunodeficiency syndrome. Clin. Immunol. , 36, 141-50. V. and Toniola, A. (1992) Acute HIV-1 infection of CD4+ human lung fibroblasts. AIDS, 6, 232-34. , Evans, L. et al. (1988) Human immunodeficiency virus recovery from bronchoalveolar lavage fluid in patients with AIDS.

Furthermore, alveolar macrophages but not blood monocytes Immune responses to HIV expressed increased levels of LPS-stimulated mRNA for TNFa, IL-1~, IL-6, during both early and late stages of HIV -1 infection regardless of virus load. This suggests that alveolar macrophages may serve as a reservoir for virus in the late stages of disease and yet contribute to immunopathogenesis of lung disease in both early and late stages through increased cytokine production. Macrophage-HIV relationship There are important differences in the outcome of HIV infection of monocytesl tnacrophages as compared to CD4 lymphocytes.

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