By G. F. Rossi (auth.), Professor Jan Gybels, Professor Edward R. Hitchcock, Priv.-Doz. Christoph Ostertag, Professor Gian Franco Rossi, Professor Jean Siegfried, Professor Gabor Szikla (eds.)
Local interstitial radiation remedy of intrinsic and inaccessible mind tumors is faced with significant difficulties: 1. The tolerance of standard mind tissue, that's frequently concerned with neighborhood tumor irradiation, i.e. perifocal white topic edema and demyelinating results, is important. 2. facts on radiation results of implanted radioactive resources on neoplastic tissue, i.e. information at the radiosensitivity and at the biology of tumors, are nonetheless largely unavailable. In scientific perform the dose with which to accomplish a given quantity of tumor necrosis is approximately predicted. This record offers with the experimental findings of Iodine-125 and Iridium-I92 everlasting implants in fit and neoplastic mind tissue. Our personal experimental findings are correlated with experimental information on Yttnul11-l)O irradiation from the literature. The research is directed to gather facts at the tolerance non-tumoral mind tissue and to try to set up a dose-response courting. Morphologic alterations within the puppy mind Following Interstitial Iodine-125 Irradiation Iodine-I25 seeds (manufactured through three M corporation, St. Paul, M. N.) with an task of 3.55 mCi have been completely implanted below stereotactic stipulations into the subcortical white subject of the gyrus coronalis of the left hemisphere in 6 beagle canine. One animal with a non-radioactive seed implanted below related operative stipulations served as a keep watch over. The animals have been allowed to outlive 25, forty six, seventy one, ninety four, 248, 368 days, respectively, after the implantation. The keep an eye on animal survived forty six days. a close description of the experimental method is given in other places sixteen. 17.
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Extra resources for Advances in Stereotactic and Functional Neurosurgery 6: Proceedings of the 6th Meeting of the European Society for Stereotactic and Functional Neurosurgery, Rome 1983
The FDG analysis program written by one of us (ACE), is based on the Phelps et al. 16 model, including the K 4 rate constant. Values for the rate constants K 1 to K 4 as well as for the lumped constant are those established by Huang et al. 9. A rearrangement of the operational equation, suggested by Brooks 3, has been incorporated. In order to display three-dimensional mapping of rCMRGl, a program has been developed to display sagittal or coronal cuts through the same distribution by recordering and interpolating the existing data.
10. Lopes da Silva, F. , Detection of non-stationarities in EEGs using the autoregressive model. An application to EEG of epileptics. ), pp. 180---199. Stuttgart: G. Fischer. 1975. II. Lopes da Silva, F. , Computer-assisted EEG diagnosis: pattern recognition in EEG analysis, feature extraction and classification. , Lopes da Silva, F. ), pp. 685-711. Baltimore-Munchen: Schwarzenberg. 1982. 12. Mars, N. J. , Computer-augmented Analysis of Electroencephalogram in Epilepsy. Proef Schrift, Enschede, Holland, 1983.
1 to avoid the practical difficulties associated with the transmission method, 4. removal of scattered events using a deconvolution procedure similar to that of Bergstrom et al. z, developed independently at AECL, 5. accurate cross calibration between the Therascan system and the well counter. Some of the oxygen-I5 studies were performed with our Positome III system, a prototype ofTherascan 3128 developed here at the Montreal Neurological Institute 15. Characteristics of Positome III have been described elsewhere 15.