AIDS and Respiratory Medicine by Jacques Chrétien, Donald A. Enarson (auth.), Alimuddin Zumla

By Jacques Chrétien, Donald A. Enarson (auth.), Alimuddin Zumla BSc MB ChB MSc PhD FRCP, Margaret Johnson MD, FRCP, Robert Miller MB FRCP (eds.)

In the 15 years of the obtained immunodeficiency syndrome (AIDS) pandemic a lot has been learnt approximately its common background and issues. it's transparent that the lung is a huge goal organ either for the human immunodeficiency virus (HIV), and a big selection of infectious and non-infectious pulmonary problems. loads of details at the epidemiology, microbiology, immunology, medical positive factors, analysis and administration of those pulmonary issues has accrued in the past 15 years. Given the large explosion in info, it's now well timed to collect this information during this 25-chapter quantity on AIDS and respiration drugs. The members to this quantity are favorite epidemiologists, medical professionals, microbiologists and scientists from Europe, united states and Africa. Professors Chretien and Enarson provide a masterful account of the epidemiology of lung issues of HIV. Drs Zumla, Rowland­ Jones and Professor McMichael supply an in depth precis of the lung immune responses to HIV. They define general lung defenses and talk about the implications of HIV an infection on them. The pulmonary radiological good points of HIV and its problems as noticeable within the united states and Europe are illustrated by way of Professors Armstrong and Dee and this can be in comparison and contrasted by means of Professor Tshibwabwa-Tumba who brings jointly his large adventure of chest X-rays in AIDS sufferers from imperative Africa. Drs O'Doherty and Miller care for the makes use of, and power purposes, of nuclear drugs in imaging of the chest in AIDS patients.

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Extra resources for AIDS and Respiratory Medicine

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AIDS Res. Hum. , 6, 431-4l. , Gehr, P. et al. (1982) Cell number and cell characteristics of the normal human lung. Am. Rev. Respir. , 126, 332-37. E. J. (1985) Evaluation of natural killer activity in patients with persistent and generalized lymphadenopathy and acquired immunodeficiency syndrome. Clin. Immunol. , 36, 141-50. V. and Toniola, A. (1992) Acute HIV-1 infection of CD4+ human lung fibroblasts. AIDS, 6, 232-34. , Evans, L. et al. (1988) Human immunodeficiency virus recovery from bronchoalveolar lavage fluid in patients with AIDS.

Furthermore, alveolar macrophages but not blood monocytes Immune responses to HIV expressed increased levels of LPS-stimulated mRNA for TNFa, IL-1~, IL-6, during both early and late stages of HIV -1 infection regardless of virus load. This suggests that alveolar macrophages may serve as a reservoir for virus in the late stages of disease and yet contribute to immunopathogenesis of lung disease in both early and late stages through increased cytokine production. Macrophage-HIV relationship There are important differences in the outcome of HIV infection of monocytesl tnacrophages as compared to CD4 lymphocytes.

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