Allergy by Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

By Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

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LFA-1 VLA-4 Leukocyte ICAM-1 VCAM-1 Endothelium Interstitial space Eosinophil Mononuclear cell Chemokine concentration gradient Inflammatory cell migration Chemokine release Epithelium Site of inflammation + IL-1, TFNα, IL-4 Fig. 29 Chemokines in leukocyte recruitment. g. eosinophil) adhere to endothelial adhesion molecules, diapedese between endothelial cells, and migrate along the chemokine gradient towards the site of inflammation. g. g. vascular cell adhesion molecule-1 (VCAM-1) or intercellular adhesion molecule-1 (ICAM-1)].

For example, were they carried out in populations of similar genetic ancestry, or with similar environmental exposures? Were exactly the same polymorphisms studies in the gene and was the phenotype tested the same?  Source: Holloway JW, Yang IA, Holgate ST. Genetics of allergic disease. J Allergy Clin Immunol 2010; 125(2 suppl 2):S81–94. A positive association between the phenotype and the allele will occur if the allele is the cause of, or contributes to, the phenotype. This association would be expected to be replicated in other populations with the same phenotype, unless there are several different alleles at the same locus contributing to the same phenotype, in which case association would be difficult to detect, or if the trait was predominantly the result of different genes in the other population (genetic heterogeneity), or depended on interaction with an environmental exposure not present in the replication population.

G. g. side-effect profile). e. nose, lung, skin)  Cytokines, chemokines, and adhesion molecules play a key role in regulating the immune and inflammatory responses during episodes of allergic inflammation  Anti-IgE, leukotriene antagonists, and anti-IL-5 are examples of therapies that have targeted specific pathways associated with allergic inflammation  Acknowledgement The authors acknowledge the contributions of Natalija Novak, Thomas Bieber and Patrick G Holt (Ch. 19; 3rd edition), Catherine M Hawrylowicz, Donald W 31 1 Introduction to mechanisms of allergic disease MacGlashan, Hirohisa Saito, Hans-Uwe Simon, Andrew J Wardlaw (Ch.

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